Postdoc in MRC Protein Phosphorylation at University of Dundee , UK-PhD Biochemistry, Immunology -Apply

Description & Details: Applications are invited for the above vacancy to work in the laboratory of Kris Clark on a project aimed at unraveling the molecular networks that promote the resolution of inflammation. The lab has recently identified a key role for the SIK family of protein kinases in regulating the phenotypic switch of macrophages from a pro-inflammatory to an anti-inflammatory state (Clark et al. PNAS 2012, 109, 16986-16991; Ozanne et al. Biochem J 2014, in press). The remarkable effects of small-molecule inhibitors of the SIKs on macrophage biology have identified these enzymes as attractive targets for the development of improved anti-inflammatory drugs. We are seeking a talented scientist whose research will lead to a greater understanding of the molecular mechanisms by which the SIKs control macrophage function. The person appointed will use state-of-the-art technologies in cell signaling, chemical biology, mass spectrometry and (phospho)proteomics to study SIK biology in primary cells from mice expressing inactive mutants of SIKs that we have recently generated.

This is a fixed-term post until 31st March 2018.

The successful candidate will be energetic and highly motivated with excellent interpersonal, organizational and communication skills. They will have an outstanding academic track record, hold a PhD in biochemistry, immunology or related discipline and have published in internationally recognized peer-reviewed journals. Preference will be given to candidates with a strong background in biochemistry, molecular and cellular biology. Experience in exploiting animal models of disease would be an advantage.

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