Postdoc in signal transduction components at University of Dundee , UK-PhD Biochemistry, Molecular Biology-Apply

Organization

Description & Details: Postdoctoral position in the Laboratory of Professor Dario Alessi FRS-to unravel the role of signalling pathways linked to understanding signal transduction pathways linked to human disease.

Applications are invited for a Postdoctoral Researcher to work in the laboratory of Dario Alessi to unravel the roles of signalling components that regulate protein phosphorylation or ubiquitylation pathways emerging from the genetic analysis of human disease.

The work would focus on analysing highly novel but poorly understood signalling components mutated in human disease implicated in diseases such as neurodegeneration or cancer.

The aim of the project will be to undertake research to discover how signal transduction components function and are regulated. It will also be critical to comprehend how mutations in these components cause human disease. It is anticipated that the knowledge gleaned from the successful candidates research could ultimately be exploited to devise improved strategies to treat human disease.

The successful applicant will deploy a state-of-the-art blend of biochemical, proteomic, pharmacological and genetic methodologies including CRISPR/CAS9 knock-out and knock-in technology. There would also be strong opportunities for interactions with the six major Pharmaceutical companies supporting the Division of Signal Transduction Therapy (DSTT see http://www.ppu.mrc.ac.uk/overview/DSTT.php) to accelerate the exploitation of discoveries.

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